The most effective treatment for the pain of knee osteoarthritis may be an injection of hyaluronic acid or corticosteroids, and the least effective may be Tylenol or Celebrex pills, a review of studies concludes.

The analysis, in Annals of Internal Medicine, reviewed 137 randomized trials involving more than 33,000 patients. Treatments included acetaminophen (Tylenol), diclofenac, ibuprofen, naproxen, celecoxib (Celebrex), corticosteroid and hyaluronic acid injections, and oral and injected placebos.

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